How to manage your tension Headache

tension-headache
tension-headache

A lot of customers order fioricet online for relief of tension headache. A tension headache is pain or discomfort in your head, scalp, or neck. A tension headache occurs when neck and scalp muscles become tense, or contract. The muscle contractions can be a response to stress, depression, a head injury, or anxiety. A tension headache (tension-type headache) is the most common type of headache, and yet its causes aren’t well understood.

The cause of tension headache is not known. Experts used to think tension headaches stemmed from muscle contractions in the face, neck and scalp, perhaps as a result of heightened emotions, tension or stress. But research suggests muscle contractions aren’t the cause.

The most common theories support a heightened sensitivity to pain in people who have tension headaches and possibly a heightened sensitivity to stress. Increased muscle tenderness, a common symptom of tension headache, may result from a sensitized pain system.

Tension-type headache  is a significant cause of sickness absence and impaired ability at work.  Tension Headache is classified as a primary headache according to the International Classification of Headache Disorders. It is a very common form of headache and can be:

  • Episodic Tension Headache (affects 78% of the population). This occurs on fewer than 15 days each month. It can evolve into the chronic variety.
  • Chronic Tension Headache (affects 3% of the population). This occurs on more than 15 days each month and has all the features of the episodic Tension Headache.

Tension headaches can last from 30 minutes to 7 days.

If you have a headache on 15 or more days each month over a 3-month period, you may have chronic tension headaches. This type of headache can lead to stress and depression, which in turn can lead to more headaches.

Triggers of Tension Headaches

A variety of foods, activities, and stress can cause these types of contractions. Some people develop tension headaches after staring at a computer screen for long hours or driving for long periods. Cold temperatures may also trigger a tension headache in some people.

Other factors that may trigger a tension headache include:

  • drinking alcohol
  • anxiety
  • depression
  • Poor posture
  • Poor sleep
  • Stress
  • Muscular tightness
  • eye strain
  • fatigue
  • smoking
  • a cold or flu
  • a sinus infection
  • caffeine
  • Usually relieved by simple analgesics.

57% Headaches are tension headaches. You can follow the steps here to prevent your headache. What you need more details about prevent tension headache  or cure your tension headaches?

Treatment and medicines of Tension Headaches

Some people with tension headaches don’t seek medical attention and try to treat the pain on their own. Unfortunately, repeated use of over-the-counter (OTC) pain relievers can actually cause overuse headaches.

A variety of medications, both OTC and prescription, are available to reduce the pain of a headache, including:

    • Pain relievers. Simple OTC pain relievers are usually the first line of treatment for reducing headache pain. These include the drugs aspirin, ibuprofen (Advil, Motrin IB, Diclofenac, Paracetamol:others) and naproxen (Aleve). Prescription medications include naproxen (Naprosyn), indomethacin (Indocin) and ketorolac (Ketorolac Tromethamine).
    • Combination medications. Aspirin or acetaminophen or both are often combined with caffeine or a sedative drug in a single medication. Combination drugs may be more effective than are single-ingredient pain relievers. Many combination drugs are available OTC.
    • Triptans and narcotics. For people who experience both migraines and episodic tension headaches, a triptan can effectively relieve the pain of both headaches. Opiates, or narcotics, are rarely used because of their side effects and potential for dependency.
fioricet
Fioricet is very effective for tension headache relief
  • Fioricet fioricet is a very effective headache reliever. Fioricet is consist of butalbital, apap, and caffeine.Acetaminophen is a pain reliever and fever reducer.  Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant.  It relaxes muscle contractions in blood vessels to improve blood flow.Fioricet is used to treat tension headaches that are caused by muscle contractions

Even if you are taking tension headache medicines, you still need manage your headaches. Home treatment may help you avoid headaches. You can:

      • Try to reduce stress.
      • Make sure you sleep, exercise, and eat on a regular schedule.
      • Make sure you practice good posture. Stand and sit up straight.
      • Try not to strain your eyes when you use your computer.
      • Get treatment for depression or anxiety if you have those health problems.
      • Try using a headache diary. Every time you get a headache, write down the date, the time, and what you were doing and feeling before your headache started. This may help you and your doctor find out what is causing your headaches. Then your doctor can use the diary to plan your treatment.

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Most often, you can buy cheap authentic Fioricet online more easily than you can find it at brick and mortar medical stores. This has made many individuals eager to embrace buying their own medication in this way,  as they’re able to save money and time by using the Internet to make their purchase. There is no real reason to worry about the safety of buying on the internet because US laws ask the us licensed pharmacies list the doctor’s name on the bottle that delivered to you. You can find the doctor in us doctor book.

You can buy inexpensive Fioricet online because the medical stores that stock it can have a large supply. There are sufficient customers for this medication that it can be sold in large amounts, which means that you don’t have to put up with the high prices sometimes charged simply by local pharmacies.

The online medical stores have the same obligations as do your local pharmacies where safeguarding patient privacy is concerned. There is no reason to worry about sharing your own medical information or background with these businesses, and there is no reason to worry about sending your own payment information online when you’re dealing with a reputable establishment.

Cheap Fioricet that you purchase online is the exact same medication you’d get at any other pharmacy. There is no difference in the formulation of the drug plus there is no difference in the doses available.

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The process of ordering the particular Fioricet medication is also exactly the same as would be the case at a local pharmacy. Your doctor transmits in your prescription to the on the internet pharmacy and they fill your own order. Your order is shipped and you’ll have to be present to indication for the medication to make sure that it can getting to the right person.

If you decide to buy inexpensive Fioricet online, make sure that if you’re going through a legitimate online pharmacy. One of the best ways to check is to look at their privacy policy and to make sure that they use encrypted machines for transmitting information.

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Please tell us your correct email and phone number because the doctors may call you to discuss your health conditions. You must complete your health conditions honestly because a lot of health conditions may stop you take fioricet, gabapentin.

Fioricet Tips

  • Do not overuse Fioricet because you may become addicted to it and have difficulty stopping it.
  • Over-use of Fioricet can also result in a medication-overuse headache (also known as a rebound headache) which occurs when analgesics are taken too frequently to relieve a headache.
  • Never share your Fioricet with anybody else.
  • May be administered without regards to food; although food may decrease any reported stomach upset.
  • If you have been taking Fioricet regularly, or if you think you have become addicted to it, talk to your doctor about slowly withdrawing it, as sudden withdrawal may precipitate a withdrawal syndrome (symptoms include anxiety, dizziness, hallucinations, muscle twitching, nausea, seizures, sleeplessness, or tremor).
  • Fioricet can cause sedation and affect your ability to drive or operate machinery.
  • Do not drink more than two alcoholic drinks a day if you are a man or one alcoholic drink per day if you are women and taking Fioricet.
  • Talk to your doctor if you have any side effects of concern. Seek urgent medical advice if you develop an allergic-type reaction (difficulty breathing or swallowing, rash, or facial swelling) soon after taking Fioricet.
  • Not recommended for women who are pregnant or breastfeeding.
  • Fioricet contains acetaminophen which may be “hidden” in other cough/cold medicines. The total dose of acetaminophen from any source should not exceed 4000mg per day (24 hours).
  • Talk to your doctor or pharmacist before taking any other medications or natural products with Fioricet as it can interact with a large number of drugs.

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Fioricet is a prescription headache killer, you must let your doctors know you are buying fioricet online. Off course we have US licensed doctors to review your health questionnaires and talk with you about your health conditions but our doctors approve your prescription according to your health questionnaires. Brand Fioricet is very expensive, most of online pharmacies do not sell fioricet brand directly but they sell generic fioricet. Generic fioricet has the same headache relief effects as brand fioricet. 

fioricetcheap.com does not dispense nor prescribe medication directly. It is still a US licensed pharmacy who has the final authorization to approve or deny prescription requests.

A lot of patients pain suffers like to order Gabapentin, fioricet online. Because pain is very popular in North America, and almost every person has pain experience. We all take Advil, Tylenol, aspirin to relive our pain.

But some kinds of pain can not be relived by this kind of over the counter pain medicines. We have to find another kind of pain medications.

We all know fioricet is good for headaches, and Gabapentin is good for nerve pain relief. But fioricet,  Gabapentin need prescription from doctor. A lot of people even fire fighters do not have insurance to cover their doctor fee.  A lot of street pharmacies have much more expensive Gabapentin, fioricet than online Gabapentin, and fioricet.

When you order fioricet generic, Gabapentin online, please remember to complete the health condition questionnaire very honestly and carefully. It would be best if You already have the experience of taking fioricet from your local pharmacies and your local doctors have prescribed this medicine before.  You should know the side effects and drug interaction before you order cheap fioricet online. There are a lot of medicines contains acetaminophen, butalbital, caffeine.  Please read carefully the pain relief medicines’ introduction. Never exceed the max dosages of acetaminophen, or butalbital.

The acetaminophen (Paracetamol, tylenol, APAP) is very popular pain reliever. A lot of pain medicines contain apap. You must read the drug introduction very carefully if you are talking more than two medicines. Our doctors will definitely check whether you are taking acetaminophen too much, but it is your own duty to guarantee all your medicines’ acetaminophen dosage never exceed the max dosage 3000mg per day. Because Acetaminophen eliminates acetaminophen mainly through metabolism by the liver, which breaks this drug down and eventually moves it out of the body by way of the kidneys, Too much acetaminophen will damage your liver and kidneys.

You are not allowed to take fioricet if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. Do not use Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Fioricet® (Watson Laboratories, Inc) is a combination tablet consisting of 40 mg of caffeine (1,3,7–trimethylxanthine), 325 mg of acetaminophen, and 50 mg of butalbital (5-allyl-5-isopropylbarbituric acid).  Fioricet® is primarily intended as treatment for tension headaches. Fioricet contains Butalbital, Acetaminophen, and caffeine.   

Butalbital is some kind of  Barbiturate. The average daily dose for the barbiturate addict is usually about 1500 mg. One tablet of fioricet only contains 50mg butalbital,  and the max dosage for fioricet per day is six tablets.  If you take the max dosage of fioricet, the butalbital dosage is 300mg. It is not easy to get additive if you take max dosage of fioricet.  The body mainly absorbs butalbital through the gastrointestinal tract, and then it is moved to most tissues in the body.  Butalbital leaves the body primarily through the kidneys as a drug that hasn’t been broken down.

Most of patients already have the experience of taking fioricet and they only refill fioricet for their tension headache, migraine, even cluster headache. We suggest you have your local doctors check your health conditions and write you a fioricet prescription at first time. You can refill online when your health conditions are not changed. But if your health condition changes, please go to your local doctors to check whether it is OK for you to refill Fioricet online.

You can buy fioricet, buy gabapentin online when you refill. Your doctor must know you are taking Gabapentin, or fioricet. Even if you order fioricet, order Gabapentin in our licensed US pharmacies, our US licensed doctors will review your health questionnaires very carefully to see whether you are OK to take the fioricet, to take Gabapentin from online sources.

You must complete your health questionnaires very carefully or you may give the doctor wrong information. Your tel number is very important for Doctors because they may discuss your health condition with you.

Before taking Fioricet

Do not use Fioricet if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use Fioricet if you are allergic to acetaminophen, butalbital, or caffeine, if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

To make sure Fioricet is safe for you, tell your doctor if you have:

  • liver disease, cirrhosis, a history of alcoholism or drug addiction, or if you drink more than 3 alcoholic beverages per day;
  • kidney disease;
  • asthma, sleep apnea, or other breathing disorder;
  • stomach ulcer or bleeding;
  • a history of skin rash caused by any medication;
  • a history of mental illness or suicidal thoughts; or
  • if you use medicine to prevent blood clots.

It is not known whether Fioricet will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Fioricet?

Take Fioricet exactly as prescribed. Follow all directions on your prescription label. Do not take more of this medication than recommended. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Butalbital may be habit-forming. Never share Fioricet with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away Fioricet is against the law.

Take Fioricet with food or milk if it upsets your stomach.

Store Fioricet at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Butalbital is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Fioricet dosing information

Usual Adult Dose of Fioricet for Headache:

Acetaminophen 300 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 capsule(s) orally every 4 hours as needed. Maximum daily dose: 6 doses.

Acetaminophen 325 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 tablet(s), capsule(s), or tablespoonful(s) orally every 4 hours.
Maximum daily dose: 6 doses

Acetaminophen 500 mg, butalbital 50 mg, and caffeine 40 mg:
1 tablet or capsule orally every 4 hours.
Maximum daily dose: 6 doses

Acetaminophen 750 mg, butalbital 50 mg, and caffeine 40 mg:
1 tablet orally every 4 hours.
Maximum daily dose: 5 tablets

Usual Pediatric Dose of Fioricet for Headache:

12 years and older:
Acetaminophen 300 mg, butalbital 50 mg, and caffeine 40 mg:
1 or 2 capsule(s) orally every 4 hours as needed. Maximum daily dose: 6 doses.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Fioricet can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include insomnia, restlessness, tremor, diarrhea, increased shallow breathing, uneven heartbeats, seizure (convulsions), or fainting.

What should I avoid while taking Fioricet?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

While you are taking this medication, avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice.

Fioricet side effects

Get emergency medical help if you have signs of an allergic reaction to Fioricet: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

  • confusion, seizure (convulsions);
  • shortness of breath;
  • a light-headed feeling, like you might pass out; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Fioricet side effects may include:

    • drowsiness, dizziness;
    • feeling anxious or restless;
    • drunk feeling; or
    • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Portrait of a happy successful mature female doctor with hands foldedWelcome to fioricetcheap.com, your trusted source of prescription medications. Fioricet cheap only employs highly qualified pharmacists and us licensed doctors. As you know, all US licensed pharmacists dare not send you prescriptions without valid US doctors’ prescriptions, besides, they can not send you prescriptions without the lawyer’s suggestion.  We all know DEA list fioricet (Butalbital, Acetaminophen, caffeine ) as Exempt Prescription and not controlled substance.

All Pharmacies associated are licensed to distribute in the states, you can be 100% sure to receive the same quality medication that you get from your local drug stores. To assure confidentiality and privacy our US licensed Pharmacy will fill and ship your prescription in a discreet package.

The US licensed pharmacies in our network never sell controlled substances. We will send you order ID and tracking ID together within two business days after you placed your orders. Please ignore any call from call centers and we never call customers to refill orders.

Upon receiving a valid prescription of the product you fill.  Our US licensed pharmacies will check your address and health conditions. If everything is OK, the information will delivered to a US licensed doctor, after the doctor reviewed your health conditions and approved it, it will send back to the pharmacies and the US licensed pharmacists will review it and approve the prescriptions. The last step is to print label and issue tracking ID. At least six steps will be involved to fill your order. We cannot stop the fill process once it begins.

 

Fioricet is the best headache reliever. By patient experience, it is valid for tension headache, migraine, cluster headache, and all kinds of headaches.

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Buying fioricet without a a local doctor’s prescription is possible here in fioricetcheap.com. With fioricetcheap.com, you can buy cod fioricet online, you can even buy card fioricet, visa fioricet, Mastercard fioricet online. Our card fioricet pharmacy is only for returned COD customers and we will tell you how to buy fioricet online using credit card if you have successfully accepted a COD fioricet or COD Gabapentin order.For COD fioricet orders, We only accept Money Orders of USPS for COD payment. We do not accept any personnel Check or small company money order.

If you have paid us bounced check or fraud check once, we will place you into customer blacklist, almost all online pharms share the same blacklist. You will not be possible to order prescription online any more.  You also should know your own health condition before you buy fioricet online.

Your first Fioricet or Gabapentin prescription must be approved by your local doctor. Our online doctors can approve your prescription too but our doctors’ decisions are based on your health conditions your provided to us. You must complete the health conditions very honestly. Some patients are not allowed to buy fioricet online in our network.

  1. You have porphyria;
  2. You have recently used alcohol;
  3. You have recently used sedatives, tranquilizers, or other narcotic medications;
  4. You have taken a MAO inhibitor in the past 14 days because A dangerous drug interaction could occur;
  5. You have liver , heart disease, kidney disease;
  6. You have  a history of alcoholism or drug addiction;
  7. You have asthma, sleep apnea, or other breathing disorder;
  8. You have stomach ulcer or bleeding;
  9. You have a history of skin rash caused by any medication;
  10. You have a history of mental illness or suicidal thoughts;
  11.  You use medicine to prevent blood clots;
  12. You are pregnant because your baby could become dependent on the drug;
  13. You are now breast feeding because Fioricet can pass into breast milk and may harm a nursing baby.

When you are not allowed to buy fioricet online does not mean you can not take fioricet, you must go to your local doctors and local pharmacies to get your prescription. You need your doctors and pharmacists to check you face to face.

What is Fioricet and why it can relieve headaches ?

Fioricet (Butalbital, Acetaminophen, and Caffeine Tablets, USP) is supplied in tablet form for oral administration.

Each tablet contains the following active ingredients:
butalbital USP . . . . . . . . . .50 mg
acetaminophen USP . . . . 325 mg
caffeine USP . . . . . . . . . . .40 mg

Fioricet contains Butalbital, Acetaminophen, and Caffeine. Acetaminophen is a pain reliever and fever reducer.  Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Butalbital

fioricetpharmacyButalbital is well absorbed from the gastrointestinal tract and is expected to distribute to most tissues in the body. Barbiturates in general may appear in breast milk and readily cross the placental barrier. They are bound to plasma and tissue proteins to a varying degree and binding increases directly as a function of lipid solubility.

Elimination of butalbital is primarily via the kidney (59% to 88% of the dose) as unchanged drug or metabolites. The plasma half-life is about 35 hours. Urinary excretion products include parent drug (about 3.6% of the dose), 5-isobutyl-5-(2, 3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. Of the material excreted in the urine, 32% is conjugated.

The in vitro plasma protein binding of butalbital is 45% over the concentration range of 0.5-20 mcg/mL. This falls within the range of plasma protein binding (20%-45%) reported with other barbiturates such as phenobarbital, pentobarbital, and secobarbital sodium. The plasma-to-blood concentration ratio was almost unity, indicating that there is no preferential distribution of butalbital into either plasma or blood cells.

Acetaminophen

Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.

Caffeine

Like most xanthines, caffeine is rapidly absorbed and distributed in all body tissues and fluids, including the CNS, fetal tissues, and breast milk.

Caffeine is cleared through metabolism and excretion in the urine. The plasma half-life is about 3 hours. Hepatic biotransformation prior to excretion results in about equal amounts of 1-methylxanthine and 1-methyluric acid. Of the 70% of the dose that is recovered in the urine, only 3% is unchanged drug.

What is the most important information I should know about Fioricet?

    • Butalbital, one of the drugs found in Fioricet, is habit-forming and has potential for abuse. Extended use is not recommended.Fioricet can affect your ability to drive a car or operate machinery. Do not drive a car or operate machinery while taking Fioricet until you know how this drug affects you.Avoid alcohol and other drugs that affect your central nervous system (brain and spinal cord) because they can further affect your ability to concentrate.
    • Who should not take Fioricet?Do not take Fioricet if you are allergic to butalbital, acetaminophen, or caffeine.Do not take Fioricet if you have an inherited disorder that affects the liver or bone marrow (porphyria).

What should I tell my doctor before I take the first dose of Fioricet?

    • Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Fioricet. Also, talk to your doctor about your complete medical history, especially if you have porphyria, kidney or liver disease, a history of prior substance abuse, if you drink alcohol, are pregnant, plan to become pregnant, or are breastfeeding.

What is the usual dosage?

  • The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor’s approval.Adults: The usual dose of Fioricet is 1 or 2 tablets taken every 4 hours as needed. One tablet contains 50 milligrams (mg) of butalbital, 325 mg of acetaminophen, and 40 mg of caffeine. Do not take more than 6 tablets per day.Elderly: Your doctor may prescribe a lower dose than the usual recommended dose to suit your needs.Children: Fioricet is not recommended in children <12 years old.

How should I take Fioricet?

  • Take Fioricet exactly as prescribed. Do not increase the amount you take without your doctor’s approval. Do not take more than 6 tablets per day.

What should I avoid while taking Fioricet?

      • Fioricet can cause drowsiness or dizziness. Avoid driving, operating machinery, or performing other hazardous activities while taking Fioricet.Avoid taking Fioricet with medications that affect your concentration, such as other narcotic pain relievers, general anesthetics, sleeping pills, anti-allergy medications, sedative-hypnotics, and tranquilizers (such as chlordiazepoxide). These may cause further drowsiness.Do not drink alcohol while taking Fioricet. Doing so may result in increased drowsiness and dizziness.Avoid taking other medications that contain acetaminophen, such as Tylenol. Avoid taking too much caffeine.

What are possible food and drug interactions associated with Fioricet?

    • If Fioricet is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Fioricet with any of the following: alcohol, general anesthetics, antidepressant medications in a class called monoamine oxidase (MAO) inhibitors such as phenelzine and tranylcypromine, narcotic pain relievers such as codeine or propoxyphene, other medicines that affect your brain and spinal cord (CNS depressants), sedative-hypnotics, and tranquilizers such as chlordiazepoxide.

What are the possible side effects of Fioricet?

    • Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.Side effects may include: fatal skin reactions, seizure, confusion, depression, excitement, stomach pain, dizziness, drowsiness, intoxicated feeling, lightheadedness, nausea, sedation, shortness of breath, vomiting, excessive sweating

Can I receive Fioricet if I am pregnant or breastfeeding?

    • The effects of Fioricet during pregnancy and breastfeeding are unknown. Do not breastfeed while taking Fioricet. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Fioricet?

    • Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular dosing schedule. Do not take two doses at once.

How should I store Fioricet?

    • Store at room temperature in a tight, light-resistant container.

Fioricet Pharmacokinetics

The behavior of the individual components is described below.

Butalbital

Butalbital is well absorbed from the gastrointestinal tract and is expected to distribute to most tissues in the body. Barbiturates in general may appear in breast milk and readily cross the placental barrier. They are bound to plasma and tissue proteins to a varying degree and binding increases directly as a function of lipid solubility.

Elimination of butalbital is primarily via the kidney (59% to 88% of the dose) as unchanged drug or metabolites. The plasma half-life is about 35 hours. Urinary excretion products include parent drug (about 3.6% of the dose), 5-isobutyl-5-(2, 3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. Of the material excreted in the urine, 32% is conjugated.

The in vitro plasma protein binding of butalbital is 45% over the concentration range of 0.5-20 mcg/mL. This falls within the range of plasma protein binding (20%-45%) reported with other barbiturates such as phenobarbital, pentobarbital, and secobarbital sodium. The plasma-to-blood concentration ratio was almost unity, indicating that there is no preferential distribution of butalbital into either plasma or blood cells.

Acetaminophen

Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.

Caffeine

Like most xanthines, caffeine is rapidly absorbed and distributed in all body tissues and fluids, including the CNS, fetal tissues, and breast milk.

Caffeine is cleared through metabolism and excretion in the urine. The plasma half-life is about 3 hours. Hepatic biotransformation prior to excretion results in about equal amounts of 1-methylxanthine and 1-methyluric acid. Of the 70% of the dose that is recovered in the urine, only 3% is unchanged drug.